Mild Ovarian Stimulation at Simran IVF: A Patient-Friendly Fertility Approach

At Simran IVF, located in Mohali, Chandigarh, and Amritsar, we offer mild ovarian stimulation protocols as a viable alternative for patients requiring a personalized approach to fertility treatments. This method utilizes lower doses of hormonal injections, often combined with oral medications such as clomiphene citrate, letrozole, or tamoxifen. Mild stimulation is cost-effective, reduces the risk of complications like ovarian hyperstimulation syndrome (OHSS), and offers a patient-centered approach, especially beneficial for specific categories of patients.

What is Mild Ovarian Stimulation?

Mild ovarian stimulation involves the use of lower-dose gonadotropins in combination with oral medications to encourage the ovaries to produce eggs. Unlike standard stimulation, which relies heavily on higher doses of injectable hormones, mild protocols aim to reduce medication intake and associated costs while maintaining reasonable outcomes.

This protocol is particularly beneficial for:

• Hyper-responders (e.g., PCOS patients): Reduces the likelihood of OHSS while ensuring adequate egg retrieval.
• Poor responders: Women with diminished ovarian reserve may not benefit from high-dose protocols, as lower doses yield similar results.
• Cost-conscious patients: Reducing medication and treatment costs makes IVF more accessible for repeated cycles.

How Does Mild Ovarian Stimulation Work?

The treatment typically begins on Day 2 or Day 3 of the menstrual cycle with oral medications like letrozole or clomiphene citrate. These medications stimulate the ovaries while reducing the need for high doses of injectable gonadotropins.

From Day 6, daily injections of hpHMG or recombinant FSH (300–450 units) are introduced to stimulate follicular growth. Follicular development is monitored using ultrasounds and hormone tests. When the leading follicle reaches a size greater than 14 mm, an antagonist is added to prevent premature ovulation.

The final step involves a double trigger—a combination of HCG and GnRH agonist injections—to mature the eggs. Egg retrieval is performed approximately 35 hours after administering the trigger.

Advantages of Mild Ovarian Stimulation

Mild ovarian stimulation has several benefits over standard protocols, especially for specific patient groups:

• Lower Risk of OHSS: Hyper-responders, such as women with PCOS, face reduced risks.
• Cost Efficiency: Lower medication usage reduces overall treatment costs, which is helpful for patients undergoing multiple IVF cycles.
• Patient Comfort: A less intensive regimen ensures greater physical and emotional comfort during the treatment process.

However, one limitation is the reduced number of embryos available for freezing compared to standard protocols, potentially leading to lower cumulative pregnancy rates.

Who is Suitable for Mild Ovarian Stimulation?

At Simran IVF, we recommend mild stimulation protocols for:

1. Patients with Severe PCOS: Women with AMH levels higher than 5.
2. Poor Responders: Women with very low ovarian reserve or advanced maternal age (>38 years).
3. Cost-Sensitive Patients: Those looking to minimize financial strain without compromising treatment quality.

Expertise at Simran IVF in Mohali, Chandigarh, and Amritsar

Simran IVF is a trusted fertility center offering state-of-the-art treatments tailored to individual needs. Our mild ovarian stimulation protocols are carefully designed to ensure safety and success for each patient.

Our experienced fertility specialists provide constant monitoring and personalized care, ensuring that every stage of the stimulation process aligns with your unique medical profile.