Embryo attachment, a crucial step for implantation, occurs during the receptive endometrium stage known as the window of implantation (WOI). Traditionally, this stage was believed to remain constant across all women. However, molecular analysis reveals a personalized WOI (pWOI), which is emphasized due to a shift observed in about 25% of patients experiencing recurrent implantation failure (RIF) due to endometrial issues.

We present a successful clinical case: a personalized embryo transfer (pET) following multiple unsuccessful IVF and oocyte donation attempts. This case is supported by a pilot study involving 17 oocyte donation patients who faced failed routine embryo transfers (ET). They subsequently underwent pET after receiving a personalized WOI diagnosis.

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